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  • Title: Occurrence of inhibitory histamine H2-receptors in bovine pulmonary arteries.
    Author: Mirbahar KB, Eyre P.
    Journal: Eur J Pharmacol; 1982 Feb 05; 77(4):331-4. PubMed ID: 6460644.
    Abstract:
    The spirally cut strips of bovine pulmonary artery responded with contractions to 5HT greater than histamine and relaxed to isoproterenol, impromidine and greater than dimaprit. After complete H1-blockade with mepyramine, histamine caused weak relaxation of the tissues contracted with 5HT. Mepyramine competitively antagonized histamine-induced contractions while the relaxant responses of pulmonary arteries to impromidine and dimaprit were sensitive to cimetidine. Impromidine was approximately 1000 - 5000 X more potent and 3 X more efficacious than dimaprit. Mepyramine neither potentiated nor inhibited impromidine-induced relaxations. The results suggest that while excitatory H1-receptors predominate; a small population of inhibitory H2-receptors also exist in bovine pulmonary arteries. The greater potency and efficacy of impromidine compared to dimaprit confirm that impromidine is a potent and specific H2-agonist.
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