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  • Title: Lysosomal enzyme release from the lungs after cardiopulmonary bypass.
    Author: Gnanadurai TV, Branthwaite MA, Colbeck JF, Welman E.
    Journal: Anaesthesia; 1978 Mar; 33(3):227-31. PubMed ID: 646073.
    Abstract:
    The activity of some lysosomal enzymes has been investigated in venous and arterial blood collected from patients undergoing cardiopulmonary bypass. Before bypass, there is no arterio-venous difference in the activity of n-acetyl-beta glucosaminidase, beta-glucuronidase or lysozyme. After operation, the activity of n-acetyl-beta-glucosaminidase is greater in arterial than in superior caval blood within the first 24 h after bypass, and a small arterio-venous increment in the activity of beta-glucuronidase can also be detected towards the end of the first day. The site of enzyme release has not been identified with certainty but may lie within the pulmonary circulation.
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