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  • Title: Potentiative interactions between caffeine and various teratogenic agents.
    Author: Ritter EJ, Scott WJ, Wilson JG, Mathinos PR, Randall JL.
    Journal: Teratology; 1982 Feb; 25(1):95-100. PubMed ID: 6461083.
    Abstract:
    Acetazolamide and inhibitors of DNA synthesis (hydroxyurea, 5-fluoro-2'-deoxyuridine), RNA synthesis (actinomycin D), and protein synthesis (cycloheximide, emetine) were each administered to pregnant rats together with caffeine at doses where each agent alone caused minimal embryotoxicity. Caffeine co-administered with any of the other agents induced a powerful potentiative response. It is not clear from the present experiments whether much lower caffeine dosage, as normally encountered in humans, would potentiate embryotoxicity due to other agents.
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