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  • Title: Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig.
    Author: Kanoh N, Makimoto K.
    Journal: Acta Otolaryngol; 1984; 98(1-2):98-104. PubMed ID: 6464730.
    Abstract:
    Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributions. Both Na and K concentrations were reduced in serum. In CSF, the Na concentration was markedly depressed, while the K concentration remained unchanged. Scala tympani perilymph showed a pattern of electrolyte changes similar to that in CSF. In scala vestibuli perilymph, the Na concentration was unaltered, but the K concentration was lowered. Cochlear endolymph exhibited no change of the Na concentration but there was a marked decrease in the K concentration. These changes are thought to be attributable to the indirect blockage of energy producing systems in membrane transport in the inner ear by the reserpine-induced depletion of catecholamines.
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