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  • Title: Comparison of the effect of DDE on the Ca metabolism of the eggshell gland and its subcellular fractions of the duck and the domestic fowl.
    Author: Lundholm CE.
    Journal: Acta Pharmacol Toxicol (Copenh); 1984 May; 54(5):400-7. PubMed ID: 6464784.
    Abstract:
    In a strain of ducks sensitive to the eggshell-thinning effect of p-p'-DDE, administration of 40 mg kg of the compound in the food for 45 days reduced the eggshell index (EI) by 13% and the content of calcium in the fluid of the shell gland forming an eggshell by 36%, and raised the calcium content of the shell gland mucosa by 19%, compared with the control values. DDE inhibited the translocation (secretion) of calcium between the gland mucosa and the uterine cavity. The ATP-dependent binding of Ca2+ to the subcellular fractions of the gland mucosa was reduced in DDE-treated ducks. The Ca2+ binding to a microsomal subfraction (FI) rich in fragments of the plasma membrane was reduced by 16%, whereas that to a subfraction FIII which bound Ca2+ at a very high rate was reduced by 36%. The latter may contain calcium-secreting granules of the gland. In the mitochondrial fraction the Ca2+ binding was reduced by 35%. In the domestic fowl DDE did not lower EI or interfered with the translocation of calcium between the shell gland mucosa and uterine cavity. DDE administration increased the Ca2+ binding to FI by 26%; the binding to other subfractions was not changed significantly. DDE may interfere with the stimulus-secretion mechanism of the eggshell gland in ducks through its effect on Ca2+ binding.
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