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  • Title: [Morphological and immunomorphological changes in the intestines and regional lymph nodes of gnotobiotic rats--chronic carriers of Vibrio cholerae El-Tor].
    Author: Gorskaia EM, Chakhava OV, Shustrova NM.
    Journal: Arkh Patol; 1978; 40(2):51-6. PubMed ID: 646664.
    Abstract:
    In the course of chronic carrier state of El-Tor vibrio cholerae gnotobiotic rats develop an immunomorphological reaction in the mucous membranes of the small and large intestines, Peter's patches, and mesenterial lymph nodes consisting in activation of reactive centers of follicles, hyperplasia of reticular cells, and an increase in the number of pyroninophilic plasma cells. The vibrio cholerae caused no pathological changes in enterocytes and other cells but its inoculation was accompanied by a "minor inflammation" in the intestinal wall and mesenterial lymph nodes. Eosinophilic infiltration in the intestinal tract, intensive mast cell reaction with degranulation in the small and large intestines and regional lymph nodes was observed.
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