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  • Title: Differential regulation of two microsomal epoxide hydrolases in hyperplastic nodules from rat liver.
    Author: Batt AM, Siest G, Oesch F.
    Journal: Carcinogenesis; 1984 Sep; 5(9):1205-6. PubMed ID: 6467508.
    Abstract:
    Two microsomal epoxide hydrolases of the rat liver were found to be differentially regulated in hyperplastic nodules. Whilst the activity for substrates of the well-known microsomal epoxide hydrolase with a broad substrate specificity (EHb), benzo[a]pyrene 4,5-oxide and androstene oxide (16 alpha, 17 alpha-epoxyandrosten-3-one), was greatly (approximately 5-fold) increased in the nodule microsomes and moderately (approximately 2-fold) increased in the surrounding tissue, that for the substrate of the novel microsomal epoxide hydrolase, cholesterol 5 alpha,6 alpha-oxide (EHch) remained unchanged. Since both enzymes convert endogenous steroid epoxides but with distinct structural features, this differential regulation may indicate a role of endogenous steroid epoxide(s) of a defined structure during hepatocarcinogenesis. Alternatively, this differential regulation may serve as a marker during hepatocarcinogenesis.
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