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  • Title: Gentamicin dosing in the newborn. Use of a one-compartment open pharmacokinetic model to individualize dosing.
    Author: Edgren B, Karna P, Sciamanna D, Dolanski E.
    Journal: Dev Pharmacol Ther; 1984; 7(4):263-72. PubMed ID: 6468228.
    Abstract:
    Gentamicin 2.5 mg/kg was given to 60 term and preterm neonates. Serum gentamicin concentrations were determined at 1, 7 and 11 h postinfusion. Linear regression analysis was used to determine half-life and volume of distribution. From these data a new dosing regimen and a predicted steady-state peak and trough gentamicin concentration were determined for each neonate. The predicted peak and trough were compared to a measured peak or trough drawn at least 48 h later. Criteria for successful peaks were met in 93% of the patients, while criteria for successful troughs were met in 83%. Individualized gentamicin dosing in the newborn based on a one-compartment open pharmacokinetic model is a useful clinical tool in predicting peak and trough gentamicin concentrations.
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