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  • Title: Effect of norepinephrine and vasopressin on carotid sinus baroreceptor activity in the anesthetized rabbit.
    Author: Holmes AE, Ledsome JR.
    Journal: Experientia; 1984 Aug 15; 40(8):825-7. PubMed ID: 6468586.
    Abstract:
    Norepinephrine (NE) 10(-6) M or vasopressin (VP) 12.5 microU/ml were injected into the isolated carotid sinus of anesthetized rabbits. The sinus was exposed either to the arterial pressure or to a pressure controlled reservoir. Multifiber and single fiber recordings were made. Both NE and VP increased baroreceptor activity at all sinus pressures but decreased activity in a few fibers. The results are consistent with the drugs having their effects on smooth muscle fibers in the adventitia.
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