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  • Title: In vitro inactivation of the neurotoxic action of beta-bungarotoxin by the marine natural product, manoalide.
    Author: de Freitas JC, Blankemeier LA, Jacobs RS.
    Journal: Experientia; 1984 Aug 15; 40(8):864-5. PubMed ID: 6468604.
    Abstract:
    The irreversible neurotoxic action of beta-bungarotoxin (beta-BuTx) can be prevented by preincubation of the toxin with manoalide, a non-steroidal anti-inflammatory agent. Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine. PLA2 is a component found in several neurotoxic venoms and is also a rate limiting enzyme important in phospholipid metabolism and prostaglandin synthesis in man.
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