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  • Title: Regulation of phosphatidylcholine biosynthesis by the methylation pathway in rat pituitary gland.
    Author: Prasad C, Edwards RM.
    Journal: Horm Metab Res; 1984 Aug; 16(8):431-4. PubMed ID: 6469209.
    Abstract:
    Rat pituitary extracts catalyze methylation of phosphatidylethanolamine to phosphatidylcholine using S-adenosyl-L-methionine as the methyl donor. In vitro incubation of hemipituitaries with 1 mM 2-methylaminoethanol led to a dose dependent decrease in phosphatidylethanolamine methyltransferase activity as well as the incorporation of the radioactivity from [3H-methyl]-L-methionine into phosphatidyl-choline. The inhibitory effect of 2-methylaminoethanol was selective for phospholipids methylation since protein carboxymethyltransferase and catechol-o-methyltransferase activities were not affected.
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