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  • Title: Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels.
    Author: Russo A, Mitchell JB.
    Journal: Int J Radiat Oncol Biol Phys; 1984 Aug; 10(8):1243-7. PubMed ID: 6469745.
    Abstract:
    Cellular glutathione (GSH) levels were modulated by either inhibition of GSH synthesis by buthionine sulfoximine (BSO) or elevation of GSH by treatment with 2-oxo-thiazolidine-4-carboxylate (OTZ), cobaltous chloride, or cysteamine. Using these agents, X ray survival in air was assessed as a function of cellular GSH levels. Depletion of GSH by BSO to less than 5% of control values resulted in slight sensitization of the aerated curve. However, elevation of GSH by as much as 200 to 300% of controls provided no radioprotection in air. These data are discussed in the context of the role of GSH and GSH peroxidase in the detoxification of peroxides produced by X rays.
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