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  • Title: Effects of histamine, serotonin, and norepinephrine on circulation of dog lungs.
    Author: Rippe B, Allison RC, Parker JC, Taylor AE.
    Journal: J Appl Physiol Respir Environ Exerc Physiol; 1984 Jul; 57(1):223-32. PubMed ID: 6469783.
    Abstract:
    The action of histamine (H), serotonin (5-HT), and norepinephrine (NE) on the lung vasculature was evaluated in isolated blood-perfused dog lung lobes using isogravimetric techniques. Pre- and postcapillary resistances, isogravimetric capillary pressure (Pc,i), capillary filtration pressure (Pc,f), capillary filtration coefficient (Kf,c), and vascular pressure-volume relationships were measured. For constant-flow conditions, all drugs induced marked increases in both pre- and postcapillary resistances and increased Pc,f. The rise in Pc,f was most pronounced for H and least marked for NE and 5-HT. For constant-pressure perfusion, Pc,f increased slightly for H but not for NE and 5-HT, while total vascular resistance increased 4-5 times for all drugs. Vascular distensibility and volumes decreased markedly for NE and 5-HT but only slightly for H. None of the drugs appeared to alter capillary permeability because Kf,c and Pc,i measured during the infusions were not different from control.
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