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  • Title: A magnetic viscometer for shear-sensitive macromolecules.
    Author: Brust R, Muth V.
    Journal: J Biochem Biophys Methods; 1984 Jul; 9(3):221-31. PubMed ID: 6470401.
    Abstract:
    This paper is a report about a rotation-viscometer with a submerged rotor which has been developed for measuring the viscosity of biological macromolecules. The device avoids the effects of surface disturbance. The rotor is centered and height-balanced electromagnetically and is controlled by a light barrier. The driving force is a rotating electromagnetic field and rotor revolution periods are measured by an electronic timer controlled by a second ligh barrier. Shearing effects are negligible if very slow revolutions are pre-selected; thus, intrinsic viscosity values for DNA can be obtained by merely extrapolating the concentration dependence. In contrast to DNA, chromatin has a very low viscosity with almost no dependence on concentration. If the ionic strength of a chromatin solution is decreased, the viscosity increases due to structural unfolding.
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