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  • Title: The clinical and neuroendocrine features of psychotic depression.
    Author: Coryell W, Pfohl B, Zimmerman M.
    Journal: J Nerv Ment Dis; 1984 Sep; 172(9):521-8. PubMed ID: 6470694.
    Abstract:
    The authors compared 65 patients with major depression and psychotic features to 192 patients with major depression and no psychotic features in terms of clinical features, family history, and hypothalamic-pituitary-adrenocortical axis function. In accord with other studies, patients with psychotic depression were more likely to have bipolar depression, psychomotor disturbance, a family history of schizophrenia, and a more severely disordered hypothalamic-pituitary-adrenocortical axis. Whether psychotic depression is best considered apart from nonpsychotic depression or as simply a more severe form of depression remains unsettled. Nevertheless, research to date does give the diagnosis of psychotic depression a practical significance which is enhanced by its simplicity.
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