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  • Title: [Changes in peroxidation under conditions of 3,4-benzypyrene-induced carcinogenesis].
    Author: Lankin VE, Gerasimov AM, Poliakov VM, Koroleva LA, Antonenkov VD, Gurpvich SM.
    Journal: Biokhimiia; 1978 Feb; 43(2):235-9. PubMed ID: 647073.
    Abstract:
    The activities of enzymatic systems generating and destroying peroxides and the lipid peroxide content in neoplastic rat liver and 3,4-benzpyrene-induced sarcoma were studied. The tumour was characterized by high activity of glutathione peroxidase and low activity of catalase. No urate- and glycolate oxidases or ascorbat dependent peroxidation of lipids and lipid peroxides were found in the tumour. In the liver of neoplastic animals the activities of glutathione peroxidase and NADPH-dependent system of microsomal phospholipid peroxidation and the lipd peroxides content were increased, whereas the activities of catalase and urate oxidase were decreased.
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