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  • Title: Lentigo maligna melanoma has no better prognosis than other types of melanoma.
    Author: Koh HK, Michalik E, Sober AJ, Lew RA, Day CL, Clark W, Mihm MC, Kopf AW, Blois MS, Fitzpatrick TB.
    Journal: J Clin Oncol; 1984 Sep; 2(9):994-1001. PubMed ID: 6470757.
    Abstract:
    We studied 48 patients with lentigo maligna melanoma (LMM) and compared the clinical stage I patients with non-LMM melanoma patients (matched by site and thickness) to see if prognosis differed. There was no significant difference in mortality from melanoma between the two groups (P = .68) after a mean follow-up time of five years (67.5 months for LMM, 60.5 months for non-LMM). In addition, a Cox multivariate analysis of the entire matched group showed that only thickness was significantly associated with death from melanoma (P = .0007) while histology (LMM v non-LMM) did not make a significant contribution (P = .61). Our data suggest that after accounting for primary tumor thickness and site, LMM and non-LMM have the same prognosis and biologic behavior, in contrast to the widely held belief that LMM has a better prognosis than other forms of melanoma.
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