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  • Title: Effects of petroleum hydrocarbon solvents on alkaline phosphatase of rats.
    Author: Kala A, Rao GS, Pandya KP.
    Journal: Bull Environ Contam Toxicol; 1978 Mar; 19(3):287-94. PubMed ID: 647132.
    Abstract:
    After administration of benzene, gasoline, IOMEX or petroleum ether, liver alkaline phosphatase showed over 200% increase in activity whereas kidney alkaline phosphatase activity was depressed by 50%. The pattern of separation of isoenzymes of alkaline phosphatase in liver, kidney and serum indicated involvement of one of the isoenzymes. A simple method of detecting the incipent toxicity is described.
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