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  • Title: Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin.
    Author: Curry PT, Reed RN, Martino RM, Kitchin RM.
    Journal: Mutat Res; 1984; 137(2-3):111-5. PubMed ID: 6472322.
    Abstract:
    Two naturally occurring fungal mycotoxins, sterigmatocystin and griseofulvin, were tested for induction of sister-chromatid exchanges (SCEs) in bone marrow cells of female Swiss albino mice. Sterigmatocystin gave elevated SCE frequencies at all doses tested (0.06-6.0 mg/kg). In contrast, griseofulvin, tested from 0.4 to 200 mg/kg, elevated the SCE frequency only in those mice which received doses of 100 or 200 mg/kg body weight. These results indicate that both fungal mycotoxins induce SCE in vivo and are potentially mutagenic.
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