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  • Title: [N-quaternary derivatives of tilorone].
    Author: Schulze W, Letsch G, Gutsche W, Wohlrabe K, Tresselt D.
    Journal: Pharmazie; 1984 May; 39(5):320-2. PubMed ID: 6473490.
    Abstract:
    Tilorone (free base) reacts with alkyl halides forming quaternary ammonium salts. Bis- as well as mono quaternary compounds (2 resp. 3) were synthesized. The tilorone-bis-methoiodide (2a) was converted to several carbonyl derivatives (4 and 5). All produced compounds did not show any cytostatic activity against the murine leukemias L 1210 and P 388 in vivo. Especially the bis-quaternary derivatives 2 were highly toxic in the mouse.
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