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  • Title: [Blood fibronectin level in experimental burn shock].
    Author: Ermolin GA, Litvinov RI, Kharin GM, Efremov EE, Kotelianskiĭ VE.
    Journal: Ter Arkh; 1984; 56(6):33-5. PubMed ID: 6474375.
    Abstract:
    The blood fibronectin concentration in rats was measured by the ELISA during burn shock. Fifteen minutes after burn the fibronectin level was found to drop by 30% of the initial level on the average. Deep hypofibronectinemis lasted up to 24 h after burn. At the same time the clinical and pathomorphological picture of the shock was fairly pronounced. The survived animals demonstrated a progressive normalization of the fibronectin level. The fibronectin level completely returned to normal by the outcome of the second day after burn and then progressed to reactive hyperfibronectinemia by 70-72 h. The data obtained point to the involvement of fibronectin into the pathogenesis of burn shock, which is likely to be connected with the mechanism of reticuloendothelial system dysfunction.
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