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  • Title: HLA and complement typing in olivo-ponto-cerebellar atrophy.
    Author: Wastiaux JP, Lamoureux G, Bouchard JP, Durivage A, Barbeau C, Barbeau A.
    Journal: Can J Neurol Sci; 1978 Feb; 5(1):75-81. PubMed ID: 647501.
    Abstract:
    HLA antigen typing was carried out in a family with an autosomal dominant form of spinocerebellar degeneration [possibly olivoponto cerebellar atrophy (O.P.C.A.)--Type 1]. Eleven ataxic patients, three possibly ataxic subjects, two unrelated spouses and 13 clinically normal at risk siblings were typed for ABO and Rh blood groups, HLA-A and HLA-B antigens, C4 component of the complement and a number of other serum proteins (Clq, beta-1A, beta-1C, C5, beta-lipoproteins). No solid evidence for linkage between the ataxia gene and the HLA or C4 loci could be demonstrated in this family. Certain serum proteins, and particularly beta-lipoproteins were found to be significantly reduced in some sub-groups of subjects.
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