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  • Title: [Mediofacial necrosis and malignant centrofacial granuloma. Apropos of 8 cases and 1 with atypical localizations].
    Author: Cudennec YF, Rigaud A, Meyrand M, Tardivel M, Buffe P.
    Journal: Ann Otolaryngol Chir Cervicofac; 1984; 101(5):381-7. PubMed ID: 6476715.
    Abstract:
    Since the first descriptions by McBride and then Stewart, and later reports by wegener, numerous publications have contained data emphasizing the diagnostic and classification difficulties of these affections, 450 cases having been documented up to the present times. Findings clearly demonstrate that mediofacial necrosis differs greatly by its pathological, etiopathogenic and out come features, and particularly the localization of the lesions. Eight case were investigated, and conclusions drawn that it was important to identify the different affections grouped under the term "mediofacial necrosis", in order to isolate cases of pure malignant centrofacial granuloma, which have no detectable etiology and cannot be integrated in another nosological framework.
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