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  • Title: [Multiple lentigines syndrome. Apropos of 2 cases. Critical study of the leopard syndrome].
    Author: Colomb D, Morel JP.
    Journal: Ann Dermatol Venereol; 1984; 111(4):371-81. PubMed ID: 6476721.
    Abstract:
    With regard to 2 cases of a same family associating: multiple lentigos, osseous signs and impairment of E.C.G., the authors recall the differents visceral manifestations which can be associated to lentigos and the relative frequency of every one of them. The authors report 38 indisputable observations of the literature that associated the 2 criterions: multiple lentigos symmetrical in their distribution and histological confirmation of sun spots. The authors perfer the term: multiple lentigos syndrome to the LEOPARD syndrome. The last term (LEOPARD), in spite of his attractive character contains a part of possible associated signs (osseous signs, primordial in our observations, are not present in that syndrome). But another way, contrary to, not any observation, up to now, allowed all the symptomes present in the acrostic LEOPARD. Through it should appear difficult to define actually the scope of the multiple lentigos syndrome, the knowledge of that entity offers a real interest for the dermopath: the discovery of a symmetrical lentiginosis, extensive or not, must lead to the exploration, as well as possible, of organs susceptible to be out of order: heart, nervous system and hearing, skeleton and facial malformations, genital-organs, and also to a family inquiry.
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