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  • Title: Pinoline, a beta-carboline derivative in the serum and cerebrospinal fluid of patients with schizophrenia.
    Author: Rimón R, Airaksinen MM, Kari I, Gynther J, Venäläinen E, Heikkilä L, Ryyppö J, Palo J.
    Journal: Ann Clin Res; 1984; 16(3):171-5. PubMed ID: 6476781.
    Abstract:
    Baseline levels of pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeOTHBC) in the serum and cerebrospinal fluid (CSF) were determined with GLC-mass spectrometry in 13 unmedicated schizophrenic patients and 18 non-psychiatric controls. A detectable concentration of 6-MeOTHBC was always present, but no differences were found between the schizophrenic and the control groups. The serum and the CSF levels of 6-MeOTHBC were not significantly related to such variables as sex, age, subtype of schizophrenia, the quality and/or intensity of the psychopathological symptoms, or the duration of illness. The role of the indoleamines in the aetiopathogenesis of schizophrenia is discussed.
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