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  • Title: [Mechanisms of hemopoiesis inhibition and recovery after the administration of carminomycin and rubomycin in an experiment].
    Author: Novitskiĭ VV, Pichugina TV, Gol'dberg ED.
    Journal: Antibiotiki; 1984 Jun; 29(6):437-41. PubMed ID: 6476806.
    Abstract:
    The experiments on 766 albino non-inbred rats and 270 mice BALB/c showed that when there were no basic differences in the mechanism of the anthracycline myeloinhibitory effect associated with a decrease in the number of the exogenic trunk hemopoietic cells, inhibition of the bone marrow proliferative activity and a decreased rate of the hemopoietic elements differentiation, carminomycin induced a more pronounced and persisting impairment of the hematopoietic tissue proliferation, as compared to rubomycin on their administration in doses equivalent by the total toxicity.
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