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  • Title: Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs.
    Author: Desjardins-Giasson S, Beaubien AR.
    Journal: Antimicrob Agents Chemother; 1984 Jul; 26(1):87-90. PubMed ID: 6476817.
    Abstract:
    A commercially available radioimmunoassay kit was modified to enable us to measure, in triplicate, the amikacin concentration in 1 microliter of perilymph fluid. Amikacin levels in plasma and perilymph were measured in guinea pigs after continuous intravenous infusion at four different dosing rates. After a 4-h infusion, a good linear correlation was found between the amikacin concentration in plasma and the dosing rate. Likewise, a significant linear relationship was found between concentrations of amikacin in perilymph and plasma (y = 0.21x + 2.56; r = 0.67; n = 45) after 6 h of infusion. These results suggest nonsaturation kinetics at the concentrations used.
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