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  • Title: Kainate reversibly aggregates brain tubulin in vitro.
    Author: López-Colomé AM, Casas A.
    Journal: Biochem Biophys Res Commun; 1984 Aug 16; 122(3):925-31. PubMed ID: 6477571.
    Abstract:
    The effect of kainate, an heterocyclic analogue of glutamate on tubulin polymerization was studied. We demonstrate that kainate induces a dose-dependent aggregation of rat brain tubulin either purified by DEAE-Sephadex A-50 or in the presence of MAPs into a mesh-like structure. Such polymer is cold-, CaCl2- and colchicine-insensitive. Removal of kainate from the incubation medium yields free tubulin competent for polymerizing into normal microtubules in the presence of GTP.
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