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  • Title: Late post-learning effect of entorhinal cortex electrical stimulation persists despite destruction of the perforant path.
    Author: Gauthier M, Destrade C.
    Journal: Brain Res; 1984 Sep 17; 310(1):174-9. PubMed ID: 6478237.
    Abstract:
    In an appetitive learning task in mice, stimulation of the lateral entorhinal cortex (LEC) 30 min after training produced an improvement in retention 24 h later, as well as faster extinction of conditioning. This effect persisted in animals with bilateral lesions of the perforant path. In addition, the threshold for hippocampal after-discharges produced by LEC stimulation was raised significantly in perforant-path lesioned animals. The results indicate a functional dissociation between hippocampal and cortical mechanisms involved in memory consolidation.
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