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  • Title: Changes in collagen fibril diameters in a lathyritic connective tissue.
    Author: Shore RC, Moxham BJ, Berkovitz BK.
    Journal: Connect Tissue Res; 1984; 12(3-4):249-55. PubMed ID: 6478824.
    Abstract:
    Collagen fibril diameters were measured in molar and incisor periodontal ligaments of adult rats given aminoacetonitrile (0.15% in their drinking water). Fibrils were also measured in the periodontal ligaments of pair-fed control animals and animals fed ad libitum. The lathyrogen produced a significant change in the distribution of fibril diameters in both molars and incisors and an increase in mean fibril diameter in incisors relative to pair-fed controls. The reduced food intake of the pair-fed control group produced a significant decrease in mean fibril diameter in incisors relative to the ad libitum control group. These results that lathyrogens may affect collagen fibril diameters in an adult connective tissue in a manner similar to that previously shown for a fetal tissue.
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