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  • Title: Synthesis of early vaccinia-virus-specific enzymes under conditions of immediate early gene expression.
    Author: Zöller B, Krempien U, Jungwirth C.
    Journal: Eur J Biochem; 1984 Sep 17; 143(3):589-91. PubMed ID: 6479164.
    Abstract:
    Cycloheximide reversal experiments in chick embryo fibroblasts and mouse L-929 cells indicate that the poxvirus-induced enzymes DNA polymerase and 'alkaline' DNase are immediate early gene products of the virus. In contrast to the vaccinia-WR-coded enzyme under conditions of immediate early gene expression the cowpox-virus-induced DNA polymerase is made only in very small amounts. The studies are consistent with the notion that all poxvirus-specific early proteins may be immediate early viral gene products.
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