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  • Title: [Lipid peroxidation and bile formation in a paracetamol lesion of the liver].
    Author: Skakun NP, Shman'ko VV.
    Journal: Farmakol Toksikol; 1984; 47(4):105-8. PubMed ID: 6479308.
    Abstract:
    It has been demonstrated in experiments on male rats that liver injury induced by paracetamol is accompanied by inhibition of bile secretion and of the synthesis and secretion of bile acids, bilirubin elimination and cholesterol excretion with bile, by reduction in the cholate/cholesterol ratio. Activation of alanine-, aspartate aminotransferase and alkaline phosphatase of blood serum attests to a change in liver function. When administered in a toxic dose paracetamol induces lipid peroxidation of hepatocyte cell membranes. The correlation was established between lipid peroxidation, transaminases and alkaline phosphatase activity in blood serum and bile formation.
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