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  • Title: Morphological changes in myofibrils and glycerinated muscle fibers on treatment with cathepsins D and L.
    Author: Matsukura U, Matsumoto T, Tashiro Y, Okitani A, Kato H.
    Journal: Int J Biochem; 1984; 16(9):957-62. PubMed ID: 6479433.
    Abstract:
    Morphological changes in myofibrils and glycerinated muscle fibers on treatment with cathepsins D and L obtained from rabbit skeletal muscle were studied by phase contrast and electron microscopy. Cathepsin D degraded the Z-line and filaments adjacent to the H-zone. Cathepsin L caused the fragmentation of myofibrils, and degraded the Z-line and M-line. Both cathepsins induced disturbance of the lateral arrangement of myofibrils.
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