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  • Title: Dynamic laser light scattering studies of the micelle to vesicle transition in model and native bile.
    Author: Schurtenberger P, Mazer NA, Känzig W.
    Journal: Hepatology; 1984; 4(5 Suppl):143S-147S. PubMed ID: 6479870.
    Abstract:
    Using quasielastic light scattering, we investigated the formation of vesicles produced spontaneously by diluting a mixed micellar solution of bile salt and lecithin beyond the micellar phase boundary. The vesicles were nearly monodisperse, and their size varied between 120 to 500 A depending upon the dilution conditions. A systematic study of the dependence of the vesicle size upon the bile salt and lecithin concentration was made and interpreted in terms of a simple equilibrium model. Likewise, the particle size distribution in native bile obtained from the dog was studied. A comparison of the dilution effect on native bile and on model bile of identical biliary lipid composition provides unambiguous evidence for micellar aggregates and the occurrence of a micelle to vesicle transition in native bile.
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