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  • Title: Intracellular mechanism of quinidine action on muscle contraction. A comparison between rabbit cardiac and skeletal muscle.
    Author: Su JY, Libao RG.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1984 Jul; 326(4):375-81. PubMed ID: 6482986.
    Abstract:
    The mechanism of quinidine action on rabbit cardiac and skeletal muscle was examined with "functionally skinned" muscle-fiber preparations. By using these preparations we could correlate measurements of muscle tension with the effect of quinidine on the Ca2+ activation of the contractile proteins and on the Ca2+ uptake and release from the sarcoplasmic reticulum (SR).
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