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  • Title: Habituation of exploratory activity in mice: effects of combinations of piracetam and choline on memory processes.
    Author: Platel A, Jalfre M, Pawelec C, Roux S, Porsolt RD.
    Journal: Pharmacol Biochem Behav; 1984 Aug; 21(2):209-12. PubMed ID: 6483933.
    Abstract:
    The effects of various piracetam + choline combinations on an experimental model of memory were investigated. Mice were given two sessions in a simple photo-cell activity cage and the decrease in activity at the second session (habituation) served as an index of retention. Retention was facilitated by post-session administration of 2000 mg/kg piracetam IP and 50 mg/kg piracetam + 50 mg/kg choline IP. Similar injections of choline alone (10 to 200 mg/kg IP), piracetam alone (10 to 1000 mg/kg IP) or other combinations of piracetam and choline were without effect. These results, consistent with those reported elsewhere, suggest that piracetam can interact with choline to facilitate memory processes in mice.
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