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  • Title: Changes in some ultrastructural parameters of cortical synapses in the initial phases of kindling.
    Author: Langmeier M, Mares J.
    Journal: Physiol Bohemoslov; 1984; 33(4):367-75. PubMed ID: 6484027.
    Abstract:
    Repeated electrical stimulation of the sensorimotor region of rat cerebral cortex at 10 min intervals led to the development and progressive prolongation of self-sustained after-discharges (SSAD). One minute after the third SSAD ended, an electronoptic morphological analysis of type I synapses after Gray from the second cortical layer of the homotopic area of the unstimulated hemisphere was carried out. In the experimental animals, an 11.7% increase in the area of the presynaptic bag and a 5.5% increase in its perimeter were demonstrated. The number of agranular synaptic vesicles per constant unit area fell by 70.8%. The area of the mitochondria in the presynaptic ending increased by 49.8% and their perimeter by 16.1%. The area of the postsynaptic element increased by 34.1% and its perimeter by 15.7%. Changes in the synapses are evaluated as manifestations of exhaustion and primarily as a manifestation of ion shifts during the epileptic seizure. The findings nevertheless also testify to incipient activation of restitution mechanisms in the structures of the synaptic apparatus within a very short time after termination of the seizure.
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