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  • Title: Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: I. The role of peroxidation of membrane phospholipids.
    Author: Kagan VE, Savov VM, Serbinova EA.
    Journal: Acta Physiol Pharmacol Bulg; 1984; 10(2):73-81. PubMed ID: 6485825.
    Abstract:
    It was demonstrated that endogenous lipid peroxidation (LPO) is an effective mechanism of disassembly of endoplasmic reticulum membranes and cytochrome P-450 (P-448) in the liver. The rate of cytochrome P-450 (P-448) degradation in vivo can be regulated by free radical scavengers. The constitutive forms of cytochrome P-450 (P-448) are less sensitive to LPO induced in vivo or in vitro than the inducible ones.
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