These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Abnormalities induced in cultured rat embryos by hyperglycaemia.
    Author: Cockroft DL.
    Journal: Br J Exp Pathol; 1984 Oct; 65(5):625-36. PubMed ID: 6487540.
    Abstract:
    Rat embryos explanted at stages between primitive streak and head-fold were exposed in rotating bottle cultures to glucose levels raised by 3-15 mg/ml either throughout a 66-h culture period, or for shorter intervals near the start of culture (with the rest of the culture period at normal glucose levels). A high proportion of embryos explanted at 8 days 20 h or at 9 days and exposed to 12 mg/ml exogenous glucose for only the first or second 8-h periods of a 66-68-h culture were malformed, whereas embryos exposed for the third 8 h were relatively resistant, and embryos exposed later still were unaffected. There were indications that embryos at stages of development corresponding to the second 8-h periods in these cultures were particularly susceptible to hyperglycaemia. Embryos explanted at 9 days exhibited malformations when exposed to 6-9 mg/ml glucose throughout culture, compared with the 12-15 mg/ml shown previously to be necessary to induce anomalies in embryos explanted 12 h later.
    [Abstract] [Full Text] [Related] [New Search]