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  • Title: Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.
    Author: Bremm KD, König W, Spur B, Crea A, Galanos C.
    Journal: Immunology; 1984 Oct; 53(2):299-305. PubMed ID: 6490085.
    Abstract:
    Leukotrienes were released from human polymorphonuclear granulocytes on incubation with endotoxins and lipid A. The analysis was performed by their smooth muscle contracting properties, reversed phase high-pressure liquid chromatography and radioimmunoassay for leukotrienes C4 and D4. The active component of the lipopolysaccharides seems to be the lipid A portion.
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