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  • Title: Asymmetric mydriatic response to topical tyramine in cluster headache relatives.
    Author: Fanciullacci M, Pietrini U, Marabini S, Boccuni M, Sicuteri F.
    Journal: Int J Clin Pharmacol Res; 1984; 4(3):247-52. PubMed ID: 6490243.
    Abstract:
    A pupillometric study was performed to evaluate the mydriatic response to tyramine, a noradrenaline releaser. There were three groups of subjects: (a) 10 cluster headache patients, in an asymptomatic period; (b) 20 of their close relatives, exempt from this disease; (c) 10 healthy controls. The tyramine was instilled into both eyes of each subject. The controls displayed an isocoric tyramine-induced mydriasis but the cluster headache sufferers and their relatives showed an anisocoric mydriasis. This anisocoric mydriasis was caused by a deficient mydriatic response on one side, which in the cluster patients corresponded to the symptomatic side. The sympathetic abnormality of the iris may be the expression of a functional asymmetry in the hypothalamus. Central sympathetic asymmetry could thus represent a dysgenetic family predisposition to lateralized headache attacks.
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