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  • Title: Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH).
    Author: Adler ID, Schmaltz A, Rathenberg R, Müller D, Strasser FF, Perret R.
    Journal: Hum Genet; 1978 May 16; 42(1):50-4. PubMed ID: 649168.
    Abstract:
    Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.
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