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  • Title: Mesophase formation during cholesterol gallstone dissolution in human bile: effect of bile acid composition.
    Author: Su CC, Higuchi WI, Gilmore IT, Danzinger RG, Hofmann AF.
    Journal: J Pharm Sci; 1984 Aug; 73(8):1160-1. PubMed ID: 6491925.
    Abstract:
    Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acids. Bile taken from patients infused with ursodeoxycholic acid was found to be enriched in ursodeoxycholic acid; mesophase formation was detected in these samples but not in bile from patients infused with chenodeoxycholic acid or cholic acid.
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