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  • Title: Anti-influenza A activity of some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides: synthesis and structure.
    Author: de la Cuesta E, Ballesteros P, Trigo GG.
    Journal: J Pharm Sci; 1984 Sep; 73(9):1307-9. PubMed ID: 6491959.
    Abstract:
    Some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides (IX-XII) prepared from bicyclo[3.2.1]octan-3-one (I), were assayed in vitro against influenza A viruses. All materials showed activity similar to 1-adamantanamine hydrochloride. A 1H-NMR study revealed only one isomer at the spiro carbon atom.
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