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  • Title: Reflex cardiopulmonary responses by stimulation to type J receptors in rats exposed to NO2.
    Author: Tsubone H, Suzuki AK.
    Journal: J Toxicol Environ Health; 1984; 13(4-6):905-17. PubMed ID: 6492209.
    Abstract:
    To examine the role of the vagal pathway on the cardiopulmonary functions in NO2-exposed rats, phenyl diguanide, which stimulates type J receptors in the lungs, was injected to control and exposed rats at a constant dose. Based on a statistical test, a decrease in the heart rate (HR) after the injection was observed in the groups exposed to 20 ppm NO2 for 1.5 h and 3h, and 10 ppm for 24 h. On the other hand, an increase in respiratory rate (RR) was observed in the groups exposed to 10 ppm for 3 h and 4 ppm for 1 wk. No change in HR and RR was found in the group exposed to 0.4 ppm for 4 wk. These results suggest that the augmentation of the reflex cardiopulmonary responses due to stimulation to the type J receptors was produced by exposures with a higher concentration of NO2.
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