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  • Title: A comparative study of the behavioral effects of the locus coeruleus and the dorsal noradrenergic bundle lesions in the rat.
    Author: Verleye M, Bernet F.
    Journal: Pharmacol Biochem Behav; 1984 Sep; 21(3):357-63. PubMed ID: 6494207.
    Abstract:
    The effects of bilateral lesions of the dorsal noradrenergic bundle (DB) or of the locus coeruleus (LC) on the rat's behavior in different anxiogenic behavioral situations have been studied. The DB rats defecate less but ambulate more than shams in the open-field (O.F.); these data suggest a decrease in the reactivity of these animals to novelty. Furthermore, the LC rats have a behavior identical to that of shams in the O.F. We note moreover that the DB rats do not habituate to a novel stimulus. During the Henderson test, the behavioral inhibition of all lesioned animals seems to be less important than that of shams. These results are discussed in relation to existing hypotheses of the DB function. The lesions of DB induce a decrease in the noradrenaline (NA) cortical level and in the catecholamines level in hypothalamus. The lesions of LC produce 30% loss of forebrain NA. These results reveal a discrepancy between the effects induced by the lesioning of DB fibers and those produced by lesions of LC, which originate in the DB. The presence of non-noradrenergic elements, fibers of passage, which do not travel with the DB fibers or terminals in the LC region may be elements for interpretation.
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