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  • Title: Effects of rociverine on the human ureter: in vivo and in vitro experimental study.
    Author: Potenzoni D, Zappia L, Sacchini P, Bezzi E.
    Journal: Pharmacol Res Commun; 1984 Aug; 16(8):765-74. PubMed ID: 6494219.
    Abstract:
    An in vitro and in vivo study was conducted to verify the effects of rociverine--a new spasmolytic agent--on peristalsis in the human ureter. In vitro (human ureter strips), rociverine exerted a spasmolytic activity both on the baseline motility and on the spasm induced by direct contractants (eledoisin, KCl) or by histamine. It may therefore be concluded that rociverine is a predominantly myotropic spasmolytic. In the in vivo study, conducted in patients with cutaneous ureterostomy, the drug showed a marked inhibitory effect on the amplitude and frequency of the ureteral rhythmic spikes, without affecting the baseline tone.
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