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  • Title: Biliary excretion of metallothionein and a possible degradation product in rats injected with copper and zinc.
    Author: Sato M, Bremner I.
    Journal: Biochem J; 1984 Oct 15; 223(2):475-9. PubMed ID: 6497858.
    Abstract:
    The concentrations of metallothionein-I (MT-I) and related immunoreactive products in bile from adult female rats were measured by radioimmunoassay. Concentrations in normal animals were 20-30 ng/ml, but increased to 600 and 75 ng/ml after injection of Cu2+ and Zn2+ respectively (3 mg of metal/kg body wt.). However, only 1-2% of the biliary Cu was bound to MT, and less than 1% of the total liver MT in control or Cu2+-injected rats appeared to be secreted in intact form into bile. Other major immunoreactive components in bile from Cu2+-injected rats included an aggregated form of MT-I and a possible degradation product of the isoprotein.
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