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  • Title: Mechanism of peroxisomal 24-hydroxylation of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid in rat liver.
    Author: Björkhem I, Kase BF, Pedersen JI.
    Journal: Biochim Biophys Acta; 1984 Nov 14; 796(2):142-5. PubMed ID: 6498207.
    Abstract:
    We recently showed that the peroxisomal fraction of rat liver has a high capacity to catalyze conversion of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid and that 3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestanoic acid is an intermediate in this conversion. With use of 2H2O and 18O2, evidence is presented here that the formation of 3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestanoic acid involves intermediary formation of a delta 24-unsaturate intermediate followed by hydration.
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