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  • Title: [D-Arg]Kyotorphin-induced ipsilateral rotation: evidence for in vivo effects independent of Met-enkephalin release.
    Author: Bean AJ, Vaught JL.
    Journal: Brain Res; 1984 Nov 12; 321(2):327-31. PubMed ID: 6498522.
    Abstract:
    Kyotorphin (Tyr-Arg) and its stable analogue [D-Arg]kyotorphin were injected into the substantia nigra of rats. Intranigral [D-Arg]-kyotorphin resulted in consistent ipsilateral rotational behavior which was naloxone-reversible. In comparison, intranigral Met-enkephalin induces naloxone-sensitive contralateral rotation. These results indicate a pharmacological effect of [D-Arg]kyotorphin in the substantia nigra that would appear to be independent of Met-enkephalin release.
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